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Dignam, James J.
One or more keywords matched the following properties of Dignam, James J.
PropertyValue
keywords clinical trials
overview Dr. Dignam's primary research involves the design, conduct, and analysis of cancer clinical trials, including early development (phase I), pilot efficacy and safety (phase II), and definitive evaluation (phase III) trials. He is the Executive Director of the Statistics and Data Management Center for NRG Oncology, a National Cancer Institute sponsored multi-center clinical trials group with over 500 recruitment sites in North America and beyond and over 100 active clinical trials. Dr. Dignam's methodology interests include trial monitoring and early stopping rules, competing risks, hazard function estimation, and prognostic modeling. He also has engaged in and led investigations into sociodemographic factors such as race/ethnicity and BMI/obesity on cancer prognosis and treatment response. Courses taught include introductory biostatistics, clinical trials, survival analysis, and regression modeling methods.
One or more keywords matched the following items that are connected to Dignam, James J.
Item TypeName
Concept Clinical Trials, Phase I as Topic
Concept Randomized Controlled Trials as Topic
Concept Clinical Trials, Phase II as Topic
Concept Clinical Trials Data Monitoring Committees
Concept Clinical Trials, Phase III as Topic
Concept Clinical Trials as Topic
Academic Article Prognosis among African-American women and white women with lymph node negative breast carcinoma: findings from two randomized clinical trials of the National Surgical Adjuvant Breast and Bowel Project (NSABP).
Academic Article Breast cancer trials on trial: a case of conflicting ethical interests.
Academic Article Early stopping of a clinical trial when there is evidence of no treatment benefit: protocol B-14 of the National Surgical Adjuvant Breast and Bowel Project.
Academic Article Prognosis and treatment of patients with breast tumors of one centimeter or less and negative axillary lymph nodes.
Academic Article Prevention of invasive breast cancer in women with ductal carcinoma in situ: an update of the National Surgical Adjuvant Breast and Bowel Project experience.
Academic Article Outcomes among African-Americans and Caucasians in colon cancer adjuvant therapy trials: findings from the National Surgical Adjuvant Breast and Bowel Project.
Academic Article Findings from recent National Surgical Adjuvant Breast and Bowel Project adjuvant studies in stage I breast cancer.
Academic Article Differences in breast cancer prognosis among African-American and Caucasian women.
Academic Article Efficacy of systemic adjuvant therapy for breast cancer in African-American and Caucasian women.
Academic Article The role of cancer cooperative groups within the spectrum of cancer care.
Academic Article Is patient travel distance associated with survival on phase II clinical trials in oncology?
Academic Article Mammographic density and breast cancer after ductal carcinoma in situ.
Academic Article Effects of obesity and race on prognosis in lymph node-negative, estrogen receptor-negative breast cancer.
Academic Article Body mass index and outcomes in patients who receive adjuvant chemotherapy for colon cancer.
Academic Article Treatment of lymph-node-negative, oestrogen-receptor-positive breast cancer: long-term findings from National Surgical Adjuvant Breast and Bowel Project randomised clinical trials.
Academic Article Early viewing of noninferiority trials in progress.
Academic Article Hazard of recurrence and adjuvant treatment effects over time in lymph node-negative breast cancer.
Academic Article Re: Racial disparities in cancer survival among randomized clinical trials of the Southwest Oncology Group.
Academic Article Long-term outcomes of invasive ipsilateral breast tumor recurrences after lumpectomy in NSABP B-17 and B-24 randomized clinical trials for DCIS.
Academic Article Multiple imputation methods for inference on cumulative incidence with missing cause of failure.
Academic Article Conditional survival and the choice of conditioning set for patients with colon cancer: an analysis of NSABP trials C-03 through C-07.
Academic Article Outcomes among black patients with stage II and III colon cancer receiving chemotherapy: an analysis of ACCENT adjuvant trials.
Academic Article The use and interpretation of competing risks regression models.
Academic Article Appropriate chemotherapy dosing for obese adult patients with cancer: American Society of Clinical Oncology clinical practice guideline.
Academic Article Predictors of locoregional recurrence after neoadjuvant chemotherapy: results from combined analysis of National Surgical Adjuvant Breast and Bowel Project B-18 and B-27.
Academic Article Estimating breast cancer-specific and other-cause mortality in clinical trial and population-based cancer registry cohorts.
Academic Article Prognosis after rectal cancer in blacks and whites participating in adjuvant therapy randomized trials.
Academic Article Semiparametric models for cumulative incidence functions.
Academic Article Choice and interpretation of statistical tests used when competing risks are present.
Academic Article Redesigning radiotherapy quality assurance: opportunities to develop an efficient, evidence-based system to support clinical trials--report of the National Cancer Institute Work Group on Radiotherapy Quality Assurance.
Academic Article Patterns of missing mini mental status exam (MMSE) in radiation therapy oncology group (RTOG) brain cancer trials.
Academic Article NCI-RTOG translational program strategic guidelines for the early-stage development of radiosensitizers.
Academic Article Integrated phase II/III clinical trials in oncology: a case study.
Academic Article A nomogram for individualized estimation of survival among patients with brain metastasis.
Academic Article Bayesian approach for flexible modeling of semicompeting risks data.
Academic Article Assessing treatment benefit with competing risks not affected by the randomized treatment.
Academic Article A tissue biomarker-based model that identifies patients with a high risk of distant metastasis and differential survival by length of androgen deprivation therapy in RTOG protocol 92-02.
Academic Article Duration of androgen suppression before radiotherapy for localized prostate cancer: radiation therapy oncology group randomized clinical trial 9910.
Academic Article Building firm foundations for therapy development.
Academic Article Joint modelling of longitudinal and multi-state processes: application to clinical progressions in prostate cancer.
Academic Article Comparison of futility monitoring guidelines using completed phase III oncology trials.
Academic Article Impact of ethnic neutropenia disparity analysis in NSABP breast trials of postoperative doxorubicin (A)/cyclophosphamide (C).
Academic Article Effect of body mass index on outcomes in patients with Dukes B and C colon cancer: An analysis of NSABP randomized trials.
Academic Article Metastasis-Free Survival Is a Strong Surrogate of Overall Survival in Localized Prostate Cancer.
Academic Article Quality of Life in Patients With Low-Risk Prostate Cancer Treated With Hypofractionated vs Conventional Radiotherapy: A Phase 3 Randomized Clinical Trial.
Award or Honor Receipt Elected Fellow
Academic Article Event-Free Survival, a Prostate-Specific Antigen-Based Composite End Point, Is Not a Surrogate for Overall Survival in Men With Localized Prostate Cancer Treated With Radiation.
Academic Article Characteristics of Participation in Patient-Reported Outcomes and Electronic Data Capture Components of NRG Oncology Clinical Trials.
Academic Article Biomarker-Driven Oncology Clinical Trials: Key Design Elements, Types, Features, and Practical Considerations.
Academic Article Multicenter Clinical Cancer Research After COVID-19: A Perspective From NRG Oncology.
Academic Article Validation of a 22-Gene Genomic Classifier in Patients With Recurrent Prostate Cancer: An Ancillary Study of the NRG/RTOG 9601 Randomized Clinical Trial.
Academic Article Leveraging External Control Data in the Design and Analysis of Neuro-Oncology Trials: Pearls and Perils.
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